MDMA
From Controversial Past to Potential Future in Mental Health Treatment
WHAT IS MDMA?
The Complex History of MDMA: From 1912 to Breakthrough Therapy
The synthetic substance MDMA (3,4-methylenedioxymethamphetamine), was first synthesized in a lab in 1912 and has a complicated history. It does not appear to have been tested in humans for the following half century, but then recreational use in the United States rose dramatically in the 1970’s in cities like Chicago which contributed significantly to nightclub culture and the emergence of the electronic music genre. No official research was being done around this time, however many therapists began using it in their clinical practice underground. Unfortunately, in 1985 the DEA officially classified MDMA as a Schedule 1 substance. Despite this, recreational use of MDMA remains common with over 2 million people in the US reporting taking it in 2022 (1). Recently, a resurgence in research has occurred, particularly in the treatment of PTSD, and the FDA classified MDMA as a breakthrough therapy in 2017.
What are the Effects for MDMA?
MDMA’s Psychological and Physical Effects: Controlled Setting Opportunities
Those who report ingesting MDMA generally describe a wide array of feelings that include euphoria, love, and self-confidence. They also describe an increased ability to feel connected and empathetic towards those around them as well as a heightened ability to speak about vulnerable material. This last part is key to its promise as a treatment for PTSD; healing from traumatic events can require an ability to discuss memories and feelings related to the trauma that can otherwise be too dysregulating. MDMA stimulates the release of neurotransmitters such as serotonin, norepinephrine, and oxytocin which is thought to contribute to these psychological phenomena. It also has a wide array of physical effects ranging from increased energy and heart rate to potentially more dangerous side effects such as hyperthermia, dehydration, sweating, and nausea. While it is considered safer than many other illicit substances, there are cases of people overdosing and having significant health consequences.
Is MDMA Legal?
Will It Become an Approved PTSD Treatment?
Although it is labeled as a breakthrough therapy by the FDA, it is still a Schedule 1 substance and only legal under very specific conditions such as being enrolled in a scientific research study. The FDA recently made its official decision in August, 2024 that more research is required before they will formally approve MDMA as a treatment for PTSD. However, our hope is to work with researchers on becoming a clinical site for such studies to assist with the goal of seeking FDA approval in the future. Â
Learn More About MDMA
Discover the latest research, legal developments, and therapeutic potential of MDMA as a groundbreaking treatment for mental health conditions like PTSD. Explore how this once-controversial substance is gaining new recognition in the medical community.